Avanafil - Spedra - Stendra Analysis

Avanafil is a popular drug used to treat erectile dysfunction.

Avanafil is the active ingredient in Spedra, marketed by Laboratoire Menarini, and Stendra, marketed by Vivus.

Because of its popularity, Avanafil is one of the most widely sold drugs on the Internet, and also one of the most counterfeited on the market.

Consuming drugs ordered from dubious or illegal sites poses a health risk. It is essential to check that the online pharmacy is serious and has all the necessary authorizations.

If you have any doubts about the origin of the drug, you should carry out an analysis to certify the presence of the active ingredient and check that its dosage in the drug complies with the indicated content.

Analysis

Avanafil is analyzed by liquid chromatography coupled with UV-Visible spectrophotometric detection (HPLC-UV Visible).

Chemical name

• Chemical name: (S)-4-((3-chloro-4-methoxybenzyl)amino)-2-[(2-hydroxyéthoxy)méthyl]-1-[(3-methylpyrazin-2-yl)methyl]-6-(propylamino)pyrimidin-5(4H)-one
• Chemical formula: C23H26ClN7O3
• CAS number: 330784-47-9

Therapeutic class

• Therapeutic class: Phosphodiesterase type 5 (PDE-5) inhibitor
• Main indication: Treatment of erectile dysfunction

Description of Therapeutic Effects

Avanafil is a drug for the treatment of erectile dysfunction (male impotence). It works by increasing blood flow to the penis, facilitating an erection in response to sexual stimulation.

Mechanism of action :

• Selective, potent inhibition of phosphodiesterase type 5 (PDE-5), an enzyme that degrades cyclic GMP (cGMP).
• By blocking PDE-5, Avanafil increases levels of cGMP, leading to smooth muscle relaxation and increased vasodilation in the cavernous bodies of the penis.

Therapeutic effects :

• Rapid onset of action: the effect can be observed as early as 15 minutes after administration.
• Average duration of action: around 6 hours.

Trade names

Avanafil is marketed under several names:

• Stendra: Best-known trade name (United States).
• Spedra: Trade name in Europe and other regions.
• Generics: Generic versions may be available in certain markets under different names.

Drug dosage

Avanafil dosage is usually 50, 100 or 200 mg.

Main Manufacturers

Major manufacturers and distributors of Avanafil include:

• Vivus, Inc: Initial developer of Avanafil.
• Menarini Group: Responsible for marketing under the name Spedra in Europe and other regions.
• Mitsubishi Tanabe Pharma Corporation: License for distribution in Asia.
• Teva Pharmaceuticals: Supplier of generic versions.
• Cipla: Producer of generic formulations in emerging countries.

Precautions and side effects

Precautions:

• Contraindicated in patients taking nitrates (risk of severe drop in blood pressure).
• Use with caution in patients with severe cardiovascular disease, renal or hepatic insufficiency.
• Not recommended for men under 18 or women.
• Avoid association with alcohol or other drugs that may induce hypotension.

Common side effects:

• Headaches.
• Hot flushes.
• Nasal congestion.
• Dizziness.

Rare but serious side effects:

• Priapism (prolonged, painful erection requiring medical intervention).
• Sudden loss of vision or hearing.
• Severe allergic reactions.