Chemaicl formula of Pyrimethamine
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Pyrimethamine - Daraprim - Malocide - Fansidar Analysis

€149.00
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PYRIMETHAMINE

Laboratory analysis of drugs to certify the presence of pyrimethamine and measure its concentration.

The level of uncertainty of the pyrimethamine content analysis depends on the declination selected (Standard <20%, Precise <10% or Regulatory <5%).

Follow the instructions to send your drug to our laboratory for analysis.

Results within 15 working days of receipt of sample.

Analysis: Standard

Pyrimethamine is an antiparasitic agent mainly used in the treatment and prevention of malaria and toxoplasmosis. It acts by inhibiting parasite dihydrofolate reductase, thus blocking the synthesis of folates essential to their growth.

Consuming medicines ordered from dubious or illegal sites can be hazardous to your health. It is essential to check that the online pharmacy is reputable and fully licensed.

If you have any doubts about the origin of the drug, you should carry out an analysis to certify the presence of the active ingredient and check that its dosage complies with the indicated content.

Analysis

Pyrimethamine is analyzed by liquid chromatography coupled with UV-Visible spectrophotometric detection (HPLC-UV Visible).

Chemical name

  • Chemical name: 5-(4-chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
  • Gross formula: C12H13ClN4
  • CAS number: 58-14-0

Therapeutic class

Pyrimethamine belongs to the class of anti-malarial and anti-parasitic drugs used mainly against malaria and toxoplasmosis.

Description of therapeutic effects

Pyrimethamine acts by :

  • Inhibits parasite dihydrofolate reductase, thus preventing the synthesis of folic acid necessary for their multiplication.
  • Reinforces the action of sulfonamides when administered in combination (e.g., with sulfadoxine for malaria or sulfadiazine for toxoplasmosis).

Its main advantages are :

  • Effective against Plasmodium falciparum malaria in combination with other molecules.
  • Used to treat toxoplasmosis in combination with sulfadiazine.
  • Can be used as a preventive treatment against malaria in certain situations.

Trade names

  • Daraprim
  • Malocide
  • Fansidar (in association with sulfadoxine)

Main manufacturers

  • GlaxoSmithKline
  • Turing Pharmaceuticals
  • Roche
  • Sanofi
  • Cipla

Precautions and side effects

Precautions for use

  • Not recommended in cases of severe renal or hepatic impairment.
  • Do not use during pregnancy without medical advice, as it may affect folate metabolism.
  • Monitor blood levels in case of prolonged use, due to risk of megaloblastic anemia.
  • To be taken with a folinic acid supplement to avoid folate deficiency.

Possible side effects

  • Digestive disorders: nausea, vomiting, abdominal pain.
  • Risk of anemia, leukopenia and thrombocytopenia (decrease in red and white blood cells and platelets).
  • Skin rashes, pruritus and possible allergic reactions.
  • Headaches and dizziness.

⚠️ Drug interactions :

  • Increased risk of toxicity with methotrexate (similar mechanism of folate inhibition).
  • Caution with myelosuppressive drugs, which may aggravate the risk of anemia.
  • Reinforces the effects of sulfonamides in combination against toxoplasmosis and malaria.
PYRIMETHAMINE

Specific References

Your drug is analyzed by our expert pharmaceutical analysis laboratory.

The drug to be analyzed must be sent in at least 3 copies in its original packaging (box or vial + blister pack) in order to have all the information.

The drug to be analyzed must be sufficiently protected to avoid any deterioration or damage during transport.

The drug to be analyzed must be accompanied by the completed analysis form.

Documents to download:

The use of counterfeit or illegal medicines (without patent authorisation) presents a proven risk to patients' health:

  • Absence of the active ingredient
  • Under-dosage of the active ingredient
  • Over-dosage of the active ingredient
  • Toxic synthetic or degradation impurities
  • Presence of another active ingredient
  • Toxic excipients
  • Presence of toxic residual solvents
  • ...

The trade in counterfeit medicines is flourishing and growing exponentially with online trading. The authorities believe that more than half of all medicines sold over the Internet are counterfeit or illegal.

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Pyrimethamine - Daraprim -...

€149.00