Ibuprofen - Advil - Nurofen - Motrin - Spedifen Analysis

Ibuprofen is a popular medication used to treat fevers and mild to moderate pain. Ibuprofen is included in the World Health Organization's (WHO) list of essential medicines.

Ibuprofen is the active ingredient in Advil, marketed by Pfizer.

Due to its popularity, Ibuprofen is one of the most widely sold drugs on the Internet, and also one of the most counterfeited on the market.

Ordering drugs from dubious sites is a health risk. It is essential to check that the online pharmacy is serious and has all the necessary authorizations.

If you have any doubts about the origin of the drug, you should carry out an analysis to certify the presence of the active ingredient and check that its dosage in the drug complies with the indicated content.

Analysis

Ibuprofen is analyzed by liquid chromatography coupled with UV-Visible spectrophotometric detection (HPLC-UV Visible).

Chemical name

• Chemical name: 2-(4-isobutylphenyl)propanoic acid
• Chemical formula: C13H18O2
• CAS number: 15687-27-1

Therapeutic class

• Therapeutic class: Non-steroidal anti-inflammatory drugs (NSAIDs)
• Subclass: Analgesics, antipyretics and anti-inflammatories

Description of Therapeutic Effects

Ibuprofen is widely used to relieve pain, reduce fever and treat mild to moderate inflammation. It works by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), responsible for the production of prostaglandins, substances which contribute to inflammation, pain and fever.

• Therapeutic indications :
  
  • Mild to moderate pain: headaches, dental pain, muscle pain, menstrual pain (dysmenorrhea).
  • Inflammations: Rheumatoid arthritis, osteoarthritis, tendonitis.
  • Fever: Reduction of fever due to infections or viral diseases.
  • Musculoskeletal conditions: Lumbago, sprains, contusions.
• Main effects :
  
  • Reduced pain and sensitivity.
  • Reduces local inflammation.
  • Lower body temperature in case of fever.

Trade names

Ibuprofen is sold under various trade names, such as :

• Advil: Popular brand for pain and fever relief.
• Nurofen: Wide range of products for pain and inflammation.
• Brufen: Used mainly for inflammatory conditions.
• Motrin: Popular brand in North America.
• Ibu: Generic and economical formulations.
• Doliprane IBU: Combination formulation in certain markets.
• Spedifen: Fast-acting granulated version.

Main Manufacturers

Ibuprofen manufacturers include major pharmaceutical companies and generic producers:

• Pfizer: Manufacturer of Advil and licensed formulations.
• Reckitt Benckiser: Producer of Nurofen, a popular brand in Europe.
• Sanofi: Manufacturer of Doliprane IBU in certain markets.
• Bayer: Producer of ibuprofen in various formulations.
• Sun Pharmaceutical Industries: Supplier of generic versions worldwide.
• Cipla: Major player in generic formulations, mainly in Asia and Africa.
• Teva Pharmaceuticals: Supplier of generics in Europe and North America.
• Hikma Pharmaceuticals: Manufacturer of injectable and generic products.

Precautions and side effects

• Precautions :
  
  • Avoid prolonged or high-dose use, especially in people with a history of gastric disorders, kidney disease or heart failure.
  • Do not administer to children under 3 months of age without medical advice.
  • Contraindicated during the third trimester of pregnancy.
• Common side effects:
  
  • Gastrointestinal disorders (abdominal pain, nausea, diarrhea, dyspepsia).
  • Headaches and dizziness.
  • Mild skin reactions (rash, pruritus).
• Serious side effects:
  
  • Gastric ulcers, digestive bleeding.
  • Renal or hepatic insufficiency.
  • Severe allergic reactions (angioedema, anaphylaxis).
  • Increased cardiovascular risk with prolonged use.