Tadalafil - Cialis - Adcirca Analysis

Tadalafil is a popular drug used to treat erectile dysfunction and prostate problems.

Tadalafil is the active ingredient in Cialis and Adcirca marketed by Eli Lilly.

Because of its popularity, Tadalafil is one of the best-selling drugs on the Internet, and also one of the most counterfeited on the market.

Consuming medicines ordered from dubious or illegal websites can be hazardous to your health. It is essential to check that the online pharmacy is serious and has all the necessary authorizations.

If you have any doubts about the origin of the drug, you must carry out an analysis to certify the presence of the active ingredient and check that its dosage in the drug is consistent with the indicated content.

Analysis

Tadalafil is analyzed by liquid chromatography coupled with UV-Visible spectrophotometric detection (HPLC-UV Visible).

Chemical name

• Chemical name : (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-méthyl-2,3,6,7,12,12a-hexahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
• Chemical formula : C22H19N3O4
• CAS Number (Chemical Abstract Service) : 171596-29-5

Therapeutic class

• Therapeutic class : Phosphodiesterase type 5 (PDE5) inhibitor
• Main indication : Treatment of erectile dysfunction, benign prostatic hypertrophy (BPH) and pulmonary arterial hypertension (PAH)

Description of Therapeutic Effects

Tadalafil is used to treat erectile dysfunction by improving the ability to achieve and maintain an erection in response to sexual stimulation. It is also effective in relieving symptoms of benign prostatic hypertrophy and treating pulmonary arterial hypertension.

• Mechanism of action : Like other PDE5 inhibitors, tadalafil works by inhibiting this enzyme, which helps maintain high levels of cGMP in the smooth muscles of penile blood vessels, leading to relaxation and increased blood flow. The special feature of tadalafil is its prolonged half-life (up to 36 hours), which has earned it the nickname "the weekend pill".
• Treatment of PAH : Tadalafil helps reduce blood pressure in the lungs by relaxing the blood vessels.

Trade names

Tadalafil is available under several brand names, including :

• Cialis : Original brand, mainly used for erectile dysfunction and BPH (prastate) marketed by Eli Lilly
• Adcirca : Used to treat pulmonary arterial hypertension marketed by Eli Lilly
• Generic Tadalafil : Available under various generic names after patent expiry

Main Manufacturers

Major manufacturers of tadalafil include:

• Eli Lilly : The original manufacturer of Cialis, which launched the drug in 2003.
• Cipla : Producer of generic tadalafil, mainly in Asia and other regions.
• Mylan : Generic tadalafil supplier in several countries, including Europe and the United States.
• Teva : Another major manufacturer of generic tadalafil.
• Sun Pharmaceutical : A generic tadalafil manufacturer serving global markets.
• Aurobindo Pharma : Producer of generic versions available worldwide.

Posologies

The usual dosage of tadalafil is 5, 10 or 20 mg.

Precautions and side effects

• Precautions : As with sildenafil, tadalafil should not be taken with nitrates because of the risk of a dangerous drop in blood pressure. It is also not recommended in cases of severe heart disease or liver failure.
• Common side effects : Headache, muscle pain (especially back pain), facial flushing, indigestion, nasal congestion.
• Serious side effects : Priapism (prolonged, painful erection requiring medical intervention), sudden loss of vision or hearing, severe allergic reactions.