Glibenclamide - Daonil - Glibenese - Euglucon - Glucovance Analysis

Glibenclamide is an oral anti-diabetic medication used primarily in the treatment of type 2 diabetes. It works by stimulating insulin secretion by the pancreas, helping to lower blood glucose levels.

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If you have any doubts about the origin of the drug, you should carry out an analysis to certify the presence of the active ingredient and check that its dosage is in line with the indicated content.

Analysis

Glibenclamide is analyzed by liquid chromatography coupled with UV-Visible spectrophotometric detection (HPLC-UV Visible).

Chemical name

• Chemical name : 5-chloro-N-[2-(4-[cyclohexylcarbamoylsulfamoyl]phenyl)ethyl]-2-methoxybenzamide
• Chemical formula : C23H28ClN3O5S
• CAS number : 10238-21-8

Therapeutic class

Glibenclamide belongs to the sulfonylurea class of oral antidiabetics used to improve insulin secretion and lower blood sugar levels in patients with type 2 diabetes.

Description of therapeutic effects

Glibenclamide acts by :

• Stimulates insulin secretion by the pancreas, increasing glucose uptake by cells.
• Reduces blood glucose levels, particularly effective in patients in the early stages of type 2 diabetes.

Its main advantages are :

• Effective in rapidly reducing blood glucose levels.
• Can be combined with other antidiabetic agents such as metformin.
• Easy to administer orally.

Trade names

• Daonil
• Glibenese
• Semi-Euglucon
• Euglucon
• Glucovance (in combination with metformin)

Main manufacturers

• Sanofi
• Merck
• Sandoz
• Teva Pharmaceuticals
• Mylan

Precautions and side effects

Precautions for use

• Do not use in cases of type 1 diabetes or diabetic ketoacidosis.
• High risk of hypoglycemia, especially in cases of prolonged fasting, intense exertion or drug interaction.
• Avoid in patients with severe hepatic or renal insufficiency.
• Use with caution in the elderly, who are more sensitive to variations in blood sugar levels.

Possible side effects

• Severe hypoglycemia (confusion, sweating, palpitations, convulsions in extreme cases).
• Gastrointestinal disorders: nausea, abdominal pain, diarrhea.
• Weight gain, frequent with sulfonylureas.
• Rare allergic reactions, including skin rashes.
• Risk of cardiovascular disorders with prolonged use (to be monitored).

⚠️ Drug interactions :

• Reinforced by other antidiabetic agents, increasing the risk of hypoglycemia.
• Interactions with beta-blockers, which may mask symptoms of hypoglycemia.
• Some antifungals and antibiotics may increase its hypoglycemic effect.