Enalapril - Renitec - Vasotec - Epaned Analysis

Enalapril is an angiotensin-converting enzyme (ACE) inhibitor used primarily in the treatment of hypertension and heart failure. It acts by lowering blood pressure and improving cardiac function by reducing the heart's workload.

Enalapril is the active ingredient in Renitc, marketed by the Organon laboratory;

Consuming medicines ordered from dubious or illegal sites can be hazardous to your health. It is essential to check that the online pharmacy is serious and has all the necessary authorizations.

If you have any doubts about the origin of the drug, you should carry out an analysis to certify the presence of the active ingredient and check that its dosage is in line with the indicated content.

Analysis

Enalapril is analyzed by liquid chromatography coupled with UV-Visible spectrophotometric detection (HPLC-UV Visible).

Chemical name

• Chemical name: (S)-1-[N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-L-proline
• Gross formula: C20H28N2O5
• CAS number: 75847-73-3

Therapeutic class

Enalapril belongs to the angiotensin-converting enzyme (ACE) inhibitor class and is used for :

• Reduce blood pressure in hypertensive patients.
• Treat heart failure, by improving heart function.
• Prevent cardiovascular complications, particularly after myocardial infarction.

Description of therapeutic effects

Enalapril is a pro-drug that converts to enalaprilat in the body, inhibiting angiotensin-converting enzyme (ACE). This reduces the production of angiotensin II, a substance that causes vasoconstriction and sodium retention.

• Reduces blood pressure, by promoting blood vessel dilation.
• Reduced cardiac load, beneficial for patients suffering from heart failure.
• Protective effect on the kidneys, particularly in diabetic patients with nephropathy.

Trade names

• Renitec
• Vasotec
• Epaned (liquid form for oral administration)

Main manufacturers

• Merck
• Teva Pharmaceuticals
• Sandoz
• Mylan
• Sanofi

Precautions and side effects

Precautions for use

• Not recommended during pregnancy, as it may cause foetal malformations.
• Monitor renal function, as it may lead to renal failure in some patients.
• Beware of hyperkalemia, especially in association with potassium supplements or potassium-sparing diuretics.
• Risk of severe hypotension, particularly when first taken or in cases of dehydration.
• Avoid association with non-steroidal anti-inflammatory drugs (NSAIDs), which may reduce its efficacy and increase the risk of renal failure.

Possible side effects

• Common: persistent dry cough, hypotension, dizziness, fatigue.
• Occasional: rash, nausea, abdominal pain.
• Rare but serious: angioedema (swelling of the face and airways requiring urgent treatment), acute renal failure.

⚠️ Drug interactions: Enalapril may interact with diuretics, NSAIDs, potassium supplements and some diabetes medications, requiring dose adjustment.