Valsartan - Diovan - Tareg - Valtan Analysis

Valsartan is a drug used primarily for the treatment of hypertension, heart failure and post-myocardial infarction prevention.

Valsartan is the active ingredient in Diovan, as well as numerous generics marketed by various pharmaceutical companies.

Consuming medicines ordered from dubious or illegal websites can be hazardous to your health. It is essential to check that the online pharmacy is serious and has all the necessary authorizations.

If you have any doubts about the origin of the drug, you should carry out an analysis to certify the presence of the active ingredient and check that its dosage in the drug complies with the indicated content.

Analysis

Valsartan is analyzed by liquid chromatography coupled with UV-Visible spectrophotometric detection (HPLC-UV Visible).

Chemical name

• Nom chimique: (S)-N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphényl]-4-yl]methyl]-L-valine
• Gross formula: C24H29N5O3
• CAS number: 137862-53-4

Therapeutic class

Valsartan belongs to the class of angiotensin II receptor antagonists (ARB II or sartans).

Description of therapeutic effects

Valsartan is indicated for:

• Treatment of hypertension:
  
  • Blocks the effects of angiotensin II, a hormone that causes vasoconstriction and increases blood pressure.
• Heart failure:
  
  • Improves cardiac function by reducing the heart's workload.
• Prevention after myocardial infarction :
  
  • Reduces the risk of heart failure and improves survival after a heart attack.

Valsartan is often prescribed alone or in combination with other antihypertensive drugs such as diuretics or calcium antagonists.

Trade names

• Diovan
• Tareg
• Valtan
• Numerous generics available

Main manufacturers

• Novartis
• Teva Pharmaceuticals
• Sandoz
• Mylan

Precautions and side effects

Precautions for use

• Do not use in pregnant women, especially after the first trimester, due to the risk to the fetus.
• Regular monitoring of renal function is recommended, particularly in elderly patients or those with impaired renal function.
• Avoid in patients with a history of angioedema linked to treatment with sartans or ACE inhibitors.
• Excessive hypotension may occur at the start of treatment, especially in dehydrated patients or those on diuretics.

Possible side effects

• Common: dizziness, hypotension, fatigue.
• Occasional: hyperkalemia (excess potassium in the blood), renal failure, headaches.
• Rare but serious: allergic reactions, angioedema, liver disorders.

⚠️ Beware of batch recalls: Several batches of valsartan have been withdrawn from the market in the past due to contamination by potentially carcinogenic impurities (nitrosamines).