Itraconazole - Sporanox Analysis

Itraconazole is a triazole antifungal agent used primarily for the treatment of systemic and cutaneous fungal infections, including aspergillosis, candidiasis, onychomycosis and histoplasmosis.

Itraconazole is the active ingredient in Sporanox, marketed by Janssen Pharmaceuticals, as well as several other generics.

Consuming medicines ordered from dubious or illegal sites can be hazardous to your health. It is essential to check that the online pharmacy is reputable and fully licensed.

If you have any doubts about the origin of the drug, you should carry out an analysis to certify the presence of the active ingredient and check that its dosage in the drug complies with the indicated content.

Analysis

Itraconazole is analyzed by liquid chromatography coupled with UV-Visible spectrophotometric detection (HPLC-UV Visible).

Chemical name

• Nom chimique : (2R,4S)-rel-1-(butan-2-yl)-4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophényl)-2-(1H-1,2,4-triazol-1-ylméthyl)-1,3-dioxolan-4-yl]méthoxy]phényl]pipérazin-1-yl]phényl]-4,5-dihydro-1H-1,2,4-triazol-5-one
• Gross formula: C35H38Cl2N8O4
• CAS number: 84625-61-6

Therapeutic class

Itraconazole belongs to the triazole class of antifungals, used mainly for :

• Treatment of invasive fungal infections, including aspergillosis, histoplasmosis and blastomycosis.
• Treatment of skin infections and nail fungus (onychomycosis).
• Treatment of recurrent oral and vaginal candidiasis.

Description of therapeutic effects

Itraconazole acts by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, leading to their destruction.

• Broad antifungal spectrum: active against Aspergillus, Candida, Histoplasma and other pathogenic fungi.
• Improved bioavailability in oral solution form compared to capsules.
• Used for prevention in immunocompromised patients to avoid invasive fungal infections.

Trade names

• Sporanox
• Itraconazole Teva
• Itraconazole Mylan
• Itraconazole Sandoz
• Other generics available

Main manufacturers

• Janssen Pharmaceuticals
• Teva Pharmaceuticals
• Mylan
• Sandoz
• Pfizer

Precautions and side effects

Precautions for use

• Contraindicated in cases of hypersensitivity to azole antifungals.
• Risk of significant drug interactions with drugs metabolized by CYP3A4 (statins, anticoagulants, immunosuppressants).
• Avoid use in cases of hepatic or cardiac insufficiency (may aggravate congestive heart failure).
• Absorption optimized if taken with an acidic meal (avoid antacids).
• Not recommended during pregnancy or breast-feeding, unless absolutely necessary.

Possible side effects

• Common: nausea, vomiting, abdominal pain, diarrhea.
• Occasional: rash, headache, increased liver enzymes.
• Rare but serious: hepatotoxicity, congestive heart failure, heart rhythm disorders (QT prolongation), severe allergic reactions.

⚠️ Drug interactions: Itraconazole may increase the plasma concentration of certain drugs, necessitating dose adjustment (e.g. ciclosporin, digoxin, warfarin).