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Posaconazole - Noxafil - Posanol Analysis
€399.00
Tax included
POSACONAZOLE
Laboratory analysis of drugs to certify the presence of posaconazole and measure its concentration.
The level of uncertainty of the posaconazole content analysis depends on the declination selected (Standard <20%, Precise <10% or Regulatory <5%).
Follow the instructions to send your drug to our laboratory for analysis.
Results within 15 working days of receipt of sample.
Posaconazole is a triazole antifungal agent, mainly used for the prevention and treatment of serious fungal infections in immunocompromised patients.
Posaconazole is the active ingredient in several drugs, including Noxafil, marketed by various pharmaceutical companies.
Consuming medicines ordered from dubious or illegal websites can be hazardous to your health. It is essential to check that the online pharmacy is reputable and fully licensed.
If you have any doubts about the origin of the drug, you should carry out an analysis to certify the presence of the active ingredient and check that its dosage in the drug complies with the indicated content.
Analysis
Posaconazole is analyzed by liquid chromatography coupled with UV-Visible spectrophotometric detection (HPLC-UV Visible).
Chemical name
- Nom chimique: 4-{4-[4-(4-chlorophényl)-2,1,3-benzoxadiazol-5-yl]piperazin-1-yl}-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxamide
- Gross formula: C37H42F2N8O4
- CAS number: 171228-49-2
Therapeutic class
Posaconazole belongs to the class of triazole antifungals, used mainly for :
- Prevention of invasive fungal infections in immunocompromised patients (e.g. leukemia, bone marrow transplants).
- Treatment of invasive aspergillosis refractory to other antifungal agents.
- Treatment of Candida infections resistant to other triazoles.
- Treatment of rare mycoses such as Zygomycetes.
Description of therapeutic effects
Posaconazole acts by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, leading to their destruction.
- Broad antifungal spectrum: active against Aspergillus, Candida and Zygomycetes.
- Improved bioavailability in tablet form compared to oral suspension.
- Used prophylactically to prevent fungal infections in high-risk patients.
Trade names
- Noxafil
- Posanol
- Posaconazole Teva
- Generic forms available
Main manufacturers
- MSD (Merck & Co.)
- Teva Pharmaceuticals
- Pfizer
- Mylan
- Sandoz
Precautions and side effects
Precautions for use
- Contraindicated in patients with hypersensitivity to azole antifungals.
- May cause QT interval prolongation, increasing risk of cardiac arrhythmia.
- Dosage adjustment required in patients with hepatic impairment.
- May interact with drugs metabolized by CYP3A4, such as certain statins and immunosuppressants.
- Caution in pregnancy, as posaconazole may be teratogenic.
Possible side effects
- Common: nausea, vomiting, abdominal pain, diarrhea, fatigue.
- Occasional: increased liver enzymes, rash, headache.
- Rare but serious: hepatotoxicity, heart rhythm disorders, severe allergic reactions.
⚠️ Drug interactions: Posaconazole may increase plasma concentrations of certain drugs such as cyclosporine, tacrolimus and benzodiazepines.
POSACONAZOLE
Specific References
Your drug is analyzed by our expert pharmaceutical analysis laboratory.
The drug to be analyzed must be sent in at least 3 copies in its original packaging (box or vial + blister pack) in order to have all the information.
The drug to be analyzed must be sufficiently protected to avoid any deterioration or damage during transport.
The drug to be analyzed must be accompanied by the completed analysis form.
Documents to download:
The use of counterfeit or illegal medicines (without patent authorisation) presents a proven risk to patients' health:
- Absence of the active ingredient
- Under-dosage of the active ingredient
- Over-dosage of the active ingredient
- Toxic synthetic or degradation impurities
- Presence of another active ingredient
- Toxic excipients
- Presence of toxic residual solvents
- ...
The trade in counterfeit medicines is flourishing and growing exponentially with online trading. The authorities believe that more than half of all medicines sold over the Internet are counterfeit or illegal.
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