Voriconazole - Vfend Analysis

Voriconazole is a triazole antifungal agent, mainly used for the treatment of serious fungal infections, including invasive aspergillosis, resistant candidiasis and other systemic mycoses.

Voriconazole is the active ingredient in several drugs, including Vfend, marketed by various pharmaceutical companies.

Consuming drugs ordered from dubious or illegal websites can be hazardous to your health. It is essential to check that the online pharmacy is serious and has all the necessary authorizations.

If you have any doubts about the origin of the drug, you should carry out an analysis to certify the presence of the active ingredient and check that its dosage in the drug complies with the indicated content.

Analysis

Voriconazole is analyzed by liquid chromatography coupled with UV-Visible spectrophotometric detection (HPLC-UV Visible).

Chemical name

• Chemical name: (2R,3S)-2-(2,4-Difluorophényl)-3-(5-fluoropyrimidin-4-yl)oxy-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
• Chemical formula: C16H14F3N5O
• CAS number: 137234-62-9

Therapeutic class

Voriconazole belongs to the class of triazole antifungals, used mainly for:

• Treatment of invasive aspergillosis, a serious fungal infection affecting the lungs.
• Treatment of systemic candidiasis, particularly fluconazole-resistant candidiasis.
• Treatment of rare fungal infections (Scedosporium and Fusarium).

Description of therapeutic effects

Voriconazole acts by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, leading to their destruction.

• Broad-spectrum antifungal effect: active against Aspergillus, Candida and other pathogenic fungi.
• Good oral bioavailability: rapidly reaches effective concentrations.
• Rapid onset of action: often used in immunocompromised patients at high risk of invasive fungal infections.

Trade names

• Vfend
• Voriconazole Teva
• Voriconazole Mylan
• Generic forms available

Main manufacturers

• Pfizer
• Teva Pharmaceuticals
• Mylan
• Novartis
• Sandoz

Precautions and side effects

Precautions for use

• Contraindicated in cases of hypersensitivity to azoles.
• May cause visual disturbances (altered color perception, photophobia).
• Monitoring required in patients with hepatic or renal insufficiency.
• Risk of QT interval prolongation (cardiac rhythm disorders).
• Caution in case of pregnancy, as voriconazole may be teratogenic.

Possible side effects

• Common: nausea, headache, abdominal pain, visual disturbances.
• Occasional: elevated liver enzymes, skin reactions, photosensitivity.
• Rare but serious: hepatotoxicity, cardiac arrhythmias, severe allergic reactions.

⚠️ Possible interactions: May interact with drugs such as rifampin, phenytoin, benzodiazepines and immunosuppressants.