Amoxicilline - Clamoxyl - Amoxil - Augmentin Analysis

Amoxicillin is a popular broad-spectrum antibiotic used to treat bacterial infections. Amoxicillin is included in the World Health Organization's (WHO) list of essential medicines.

Amoxicillin is the active ingredient in Clamoxil, marketed by GlaxoSmithKline (GSK).

Due to its popularity, Amoxicilline is one of the most widely sold drugs on the Internet, and also one of the most counterfeited on the market.

Ordering drugs from dubious sites is a health risk. It is essential to check that the online pharmacy is serious and has all the necessary authorizations.

If you have any doubts about the origin of the drug, you should carry out an analysis to certify the presence of the active ingredient and check that its dosage in the drug complies with the indicated content.

Analysis

Amoxicillin is analyzed by liquid chromatography coupled with UV-Visible spectrophotometric detection (HPLC-UV Visible).

Chemical name

• Chemical name : (2S,5R,6R)-6-[(2R)-2-amino-2-(4-hydroxyphényl)acétamido]-3,3-diméthyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylique
• Chemical formula : C16H19N3O5S
• CAS number : 26787-78-0

Therapeutic class

• Therapeutic class : Antibiotic
• Sous-classe : Bêta-lactamines, pénicillines aminées

Description of Therapeutic Effects

Amoxicillin is a broad-spectrum antibiotic used to treat a wide range of bacterial infections. It is effective against Gram-positive and some Gram-negative bacteria.

• Mechanism of action: Amoxicillin acts by inhibiting bacterial cell wall synthesis. It interferes with the construction of peptidoglycans, which are essential for the strength of bacterial cell walls, leading to bacterial cell lysis and death.
• Use: It is prescribed to treat respiratory tract infections (pneumonia, bronchitis, sinusitis), throat infections, ear infections, urinary tract infections, early Lyme disease, skin infections, and gastrointestinal infections caused by bacteria such as Helicobacter pylori (in combination with other drugs).
• Prophylaxis: Used to prevent bacterial infections following certain dental surgeries, or to prevent infective endocarditis in at-risk patients.

Trade names

Amoxicillin is available under various brand names, including :

• Clamoxyl: One of the original trade names
• Amoxil: Used mainly in English-speaking countries
• Augmentin: A combination of amoxicillin and clavulanic acid (to counter beta-lactamase-producing bacteria)
• Moxatag: A sustained-release form
• Amoxicillin Teva: A generic version
• Amoxicillin Mylan: Another common generic name

Main Manufacturers

The main manufacturers of amoxicillin are :

• GlaxoSmithKline (GSK): The original manufacturer of Clamoxyl.
• Sandoz (division of Novartis): Producer of generic versions.
• Teva Pharmaceuticals: A leading producer of generics, including amoxicillin.
• Mylan: Another major manufacturer of generic amoxicillin.
• Sanofi: Producer of various amoxicillin formulations.
• Sun Pharmaceutical Industries: Supplier of generics, widely available worldwide.
• Aurobindo Pharma: One of the leading producers of generic amoxicillin, exporting worldwide.

Precautions and side effects

• Precautions: Amoxicillin is generally well tolerated, but can cause severe allergic reactions in people sensitive to penicillins. It should be used with caution in patients with a history of drug allergies. It is also important to check for interactions with other drugs, particularly methotrexate.
• Common side effects: Diarrhea, nausea, rash, abdominal pain, oral or vaginal candidiasis.
• Serious side effects: Severe allergic reactions (anaphylactic shock), pseudomembranous colitis (due to Clostridioides difficile), hepatitis, acute kidney damage, Stevens-Johnson syndrome.