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Chemical formula of Proguanil
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Proguanil - Malarone Analysis

€249.00
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PROGUANIL

Laboratory analysis of a drug to confirm the presence of proguanil and measure its concentration.

The level of uncertainty in the proguanil content analysis depends on the selected specification (Standard <20%, Precise <10%, Regulatory <5%).

Follow the instructions to send your medication to our laboratory for analysis.

Results will be available within 15 business days of receiving the sample for analysis.

Analysis: Standard

Proguanil is an antimalarial drug used primarily for the prevention and treatment of malaria, usually in combination with other active ingredients such as atovaquone. It works by disrupting folic acid synthesis in the parasite that causes malaria.

Antimalarial drugs purchased through unsafe channels may be counterfeit or underdosed, compromising the effectiveness of the treatment.

If you have any doubts about the origin of the medication, an analysis can confirm the presence of the active ingredient and verify its dosage.

Analysis conducted

Proguanil is analyzed by liquid chromatography coupled with UV-visible spectrophotometric detection (LC-UV-Vis) to ensure accurate identification and quantification.

Chemical name

  • Chemical name: N-(4-chlorophenyl)-N′-isopropylbiguanide
  • Molecular formula: C11H16ClN5
  • CAS Number: 637-32-1

Therapeutic class

Proguanil belongs to the class of antifolates used to treat malaria.

Description of therapeutic effects

Proguanil works by inhibiting the synthesis of folates necessary for the development of the Plasmodium parasite.

It is used for:

  • Prevent malaria in travelers visiting high-risk areas.
  • Treat certain forms of malaria, in combination with atovaquone.
  • Reduce the multiplication of the parasite in the body.
  • Contribute to malaria prophylaxis in endemic regions.

Trade names

  • Paludrine
  • Malarone (association atovaquone/proguanil)

Major manufacturers

  • GlaxoSmithKline (GSK)
  • Teva Pharmaceuticals
  • Zentiva
  • Mylan
  • Sun Pharmaceutical Industries

Precautions and Side Effects

Precautions for use

  • Complete the full course of preventive or curative treatment.
  • Use with caution in patients with severe renal impairment.
  • Use under medical supervision in pregnant or breastfeeding women.
  • Verify the authenticity of medications purchased online.

Possible side effects

  • Digestive problems: nausea, vomiting, abdominal pain, diarrhea.
  • Headaches and dizziness.
  • Skin reactions: rashes, itching.
  • Mouth ulcers or oral irritation (rare).
  • Rare blood disorders with prolonged use.

Possible drug interactions

Certain anticoagulants and medications that affect liver metabolism.

Other antifungal treatments that may affect therapeutic efficacy.

Warning: Counterfeit, improperly stored, or underdosed proguanil may compromise the prevention or treatment of malaria. Laboratory testing ensures the product’s compliance.

PROGUANIL

Specific References

Your drug is analyzed by our expert pharmaceutical analysis laboratory.

The drug to be analyzed must be sent in at least 3 copies in its original packaging (box or vial + blister pack) in order to have all the information.

The drug to be analyzed must be sufficiently protected to avoid any deterioration or damage during transport.

The drug to be analyzed must be accompanied by the completed analysis form.

Documents to download:

The use of counterfeit or illegal medicines (without patent authorisation) presents a proven risk to patients' health:

  • Absence of the active ingredient
  • Under-dosage of the active ingredient
  • Over-dosage of the active ingredient
  • Toxic synthetic or degradation impurities
  • Presence of another active ingredient
  • Toxic excipients
  • Presence of toxic residual solvents
  • ...

The trade in counterfeit medicines is flourishing and growing exponentially with online trading. The authorities believe that more than half of all medicines sold over the Internet are counterfeit or illegal.

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