Sildenafil - Viagra - Kamagra - Reviato Analysis

Sildenafil is a popular drug used to treat erectile and prostate dysfunction.

Sildenafil is the active ingredient in Viagra marketed by Pfizer and Kamagra marketed by Ajanta Pharma.

Due to its popularity, Sildenafil is one of the most widely sold drugs on the Internet, and also one of the most counterfeited on the market.

Consuming drugs ordered from dubious or illegal sites poses a health risk. It is essential to check that the online pharmacy is reputable and fully licensed.

If you have any doubts about the origin of the drug, you should carry out an analysis to certify the presence of the active ingredient and check that its dosage in the drug complies with the indicated content.

Analysis

Sildenafil is analyzed by liquid chromatography coupled with UV-Visible spectrophotometric detection (HPLC-UV Visible).

Chemical name

• Chemical name: 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine
• Chemical formula: C22H30N6O4S
• It is mainly marketed as sildenafil citrate
• CAS numbers: 171599-83-0 (Sildanafil citrate) and 139755-83-2 (Sildenafil)

Therapeutic class

• Therapeutic class: phosphodiesterase type 5 (PDE5) inhibitor
• Main indication: Treatment of erectile and prostate dysfunction in men, also used for pulmonary arterial hypertension (PAH)

Description of Therapeutic Effects

Sildenafil is a drug used mainly to improve erections in men suffering from erectile dysfunction (impotence). It works by increasing blood flow to the penis during sexual stimulation, thereby facilitating erection.

• Mechanism of action: Sildenafil inhibits the enzyme phosphodiesterase type 5 (PDE5), which is responsible for the degradation of cyclic guanosine monophosphate (cGMP). GMPc is a key molecule that promotes smooth muscle relaxation and vasodilation of penile arteries. By inhibiting PDE5, sildenafil enables cGMP to remain active for longer, resulting in a better erection.
• Treatment of PAH: In pulmonary arterial hypertension, sildenafil helps lower blood pressure in the lungs by relaxing blood vessels.

Trade names

Le sildénafil est vendu sous plusieurs noms de marque, les plus connus étant :

• Viagra (for erectile dysfunction, Pfizer)
• Revatio (for pulmonary arterial hypertension, Pfizer)
• Kamagra (marketed by other laboratories, often online, Ajanta Pharma)
• Various generic brands are also available.

Main Manufacturers

Les principaux fabricants du sildénafil incluent :

• Pfizer: The original manufacturer of Viagra and Revatio. Pfizer launched Viagra in 1998, becoming one of the world's most famous drugs.
• Ajanta Pharla: Producer of Kamagra
• Mylan: Producer of generic versions of sildenafil.
• Teva: Producer of generic sildenafil, available in several countries.
• Cipla: Producer of sildenafil and other drugs for PAH, particularly in developing countries.
• Sun Pharmaceutical Industries: One of the world's leading manufacturers of generic sildenafil.
• Torrent Pharmaceuticals: Manufacturer of generic versions, widely available worldwide.

Posologies

The usual dosage of sildenafil is 20, 50 or 100 mg.

Precautions and side effects

• Precautions: Sildenafil should not be taken by people using nitrate derivatives (drugs for heart pain) because of the risk of a dangerous drop in blood pressure. It should be taken under medical supervision, especially in patients with a history of heart disease.
• Common side effects: Headache, facial flushing, digestive disorders, nasal congestion, and visual disturbances (including bluish vision).
• Serious side effects: Sudden loss of vision or hearing, priapism (prolonged erection), severe hypotension.